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An instrumental variable analysis with the hospital low-dose corticosteroid prescription proportion showed that receipt of low-dose corticosteroid was significantly associated with reduction in in-hospital mortality (differences, −13.5 %; 95 % CI −24.6 to −2.3).
The small increase in post-policy ACEIs prescription proportion was not associated with any savings.
The analysis of ACEIs prescription proportion was stratified by the 13 UK regions.
Segmented time-series analysis was applied to monthly ACEIs prescription proportion, adjusted number of ACEIs/ARBs prescriptions and costs.
The regional difference between the highest (80.8 % in the North East) and lowest (60.3 % in Northern Ireland) ACEIs prescription proportion was 20.5 %.
(DOCX 35 kb) Additional file 4: Segmented regression analysis, with all the parameter estimates, on the quarterly number of antihypertensive prescriptions and ACEIs prescription proportion.
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Although the policy had no instant impact on the level (β2) of ACEIs prescriptions' proportion, it resulted in a significant increase in the trend of the ACEI prescriptions' proportion thereafter (β3: 0.1 %, p < 0.001).
Results from the HSCIC quarterly dispensing dataset analyses (Table 5, Additional file 4) showed a significant declining trend in the ACEIs prescriptions' proportion prior to the BCBV policy implementation (β1: -0.09 %, p < 0.001).
The UTB drugs are found in a list of UTB, described annually by the Directorate of Public Health (INSALUD) 4. Generic drug prescription: the proportion of prescribed generic medicines relative to the total.
Only 4.2% of patients with no contact to these specialists received a prescription, this proportion increased to 37.3% in patients with 6-9 contands and then decreased (21.5% in those with 10+ contacts).
Secondary analyses included mean change in weight (kg) calculated as for HbA1c, mean change in prescribed daily insulin dose calculated as units prescribed divided by the number of days covered by the prescription, the proportion of patients using bolus prandial insulin, and the percentage of patients achieving defined HbA1c levels.
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