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Sixty-nine (36%) patients without clinical evidence of infection received 3Gcs and prescribing was based on therapeutic recommendations in 4% of patients.
To be able to determine to what extent prescribing was based on diagnoses and if diagnoses correlated to prescribing, two different patient groups, A and B, were selected.
Classification of drug prescribing was based on one or more prescriptions, but interpretation did not differ if two or more prescriptions were used.
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This figure does not account for wastage, misdiagnosis (if, as is most likely, prescribing is based on clinical suspicion alone), or a higher rate of secondary bacterial complication than expected; it is also based on a strategy of treatment only.
The chosen cut-offs for normal and high-dose analgesia prescribing are based on the Gooch et al, 16 study which employed methodologies similar to our study and are adjusted for differences in study duration.
Therefore, the new treatment strategy prescribed was based on the physicians' criteria only.
The gradual growth over time of legislative authority and in the numbers of non-medical prescribers, particularly nurses, in some countries suggests that the acceptability of non-medical prescribing is based on the perceived value to the health care system as a whole.
The extent to which off-label prescribing is based on good clinical data is also concerning.
As paediatric prescribing is based on weight we also tracked whether clinicians documented this in the case record.
The theoretical link between the range of drugs prescribed and quality of drug prescribing is based on the use of restrictive formularies or guidelines.
Prescription compliance (calculated for each patient as total number of compliant days divided by the total number of days prescribed TRT) was based on patient diary information and could be determined in 55% (321/581) of the population; compliance rates were comparable between MetS+ and MetS- patients (90.7 ± 1.5%, n = 107 vs 93.6 ± 0.9%, n = 189, respectively; p = 0.1).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com