Taken together, these data suggested that the localization may be a major prerequisite for specific biological roles of the histone isoforms in gene expression, marking distinct regions of chromatin distribution in the nuclei.
The relatively high degree of flexibility within the L2 region may be a prerequisite for specific Hb binding to IsdBN1, supporting a "folding upon binding" model which is often observed for intrinsically disordered regions of proteins, and the plasticity of Hb-binding NEAT domain architectures.
Functional knowledge of the physiological basis of crop adaptation to stress is a prerequisite for exploiting specific adaptation to stress environments in breeding programs.
In order to obtain microparticles with long circulation times, or to provide the prerequisite for tissue specific targeting through decoration with suitable ligands, their surfaces need to be modified such that they become repellent to the adsorption of opsonic proteins and resistant to unspecific phagocytosis.
The data indicate that the presence of a G-box element is not a prerequisite for leaf specific and light induced gene expression in sugar beet.
Fundus autofluorescence, for example, is not only useful for screening patients at high-risk of DFO retinopathy, but is also a prerequisite for identify specific high-risk patterns of RPE changes that are relevant for the prognosis of the disease.
Fundus autofluorescence imaging is a prerequisite for identifying specific high-risk characteristics (such as patchy or speckled patterns) that may be helpful in the decision to discontinue or switch iron-chelating therapy to prevent disease progression and irreversible visual loss due to RPE atrophy.
To explore sequence variation within the centromeric read database and as a prerequisite for searching for specific sequence features that distinguish functional centromeres from related (but non-functional) sequences, we reformatted the entire canine unmapped database and the remaining unassigned "gap" reads into a library of k-mers (see Methods).
Actually, monocyte-specific CpG hypomethylation should be observed in promoters and likely on enhancers, as a prerequisite for lineage-specific gene expression.
Shear-induced transportation of circulating tumor cells to the target site is the prerequisite for organ-specific metastasis under blood flow (Wirtz et al., 2011) and tumor cell invasion is usually promoted by interstitial fluid affecting their interactions with stromal cells (Shieh et al., 2011).
