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Independent of positive or negative plant responses to MWCNT treatments, the direct cell contact of individual or agglomerated CNTs seems to be a prerequisite for the induction of any effects, with differences in plant sensitivity or different physical parameters of CNTs (diameter, length, degree of aggregation) as determinants for the variable expression of plant responses.
As the binding of gluten-derived peptides is a prerequisite for the induction of the inflammatory T-cell response, blockers that would prevent gluten peptide binding to the HLA-DQ molecules might be used as an alternative to the gluten-free diet.
A reduction of NANOG and OCT4 protein levels is thus a prerequisite for the induction of differentiation.
At CA3-CA1 synaprolongedrolonged but moderate increase in postsynaptic intracellular free calcium ([Ca2+]i) is a prerequisite for the induction of LTD [23], [24], [25], [26].
Although this point has not been discussed by the authors, it suggests that the ability of slices to express LTD is temporally related to rest conditions, possibly through basal intracellular free calcium [Ca2+]i concentrations, since a moderate increase in [Ca2+]i is a prerequisite for the induction of LTD [23], [24], [25], [26].
However, binding of α-MSH to a functional MC-1R was an important prerequisite for the induction of kill activity since the cytotoxic potential of α-MSH stimulated CD8+ T cells from C57BL/6Je/e mice was not altered compared to negative controls (Figure 3B).
Similar(37)
LOX activity was reported to be greater in human breast cancer than in normal tissues [ 128], a finding that suggests that LOX plays a key role in creating the cellular microenvironment necessary for a pre-cancerous niche (PCN), one of the prerequisites for the induction of cancer.
RANK signaling additionally leads to induction of c-Fos, which is a prerequisite condition for the induction of NFATc1, a master transcription factor for osteoclastogenesis.
We deliberately used the concentration of each TLR ligand that induced highest levels of mdDC maturation as fully matured DC are a prerequisite for the successful induction of Th1 responses in vivo (22).
GVH activity was shown to be a prerequisite for induction of the protective effect but was equally effective when produced by the transfer of Wistar spleen cells in place of PVGc cells.
Moreover, the activation of the SA signaling pathway may be a prerequisite for optimal induction of ET synthesis since ozone-induced ET accumulation is compromised in NahG and npr1 plants [91].
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