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Survival of implanted stem cells, as was argued in those earlier reports, was not a prerequisite for efficacy, since the stem cells may be involved in paracrine activity early after implantation, and disappear after longer periods of time [22], [32] [33].
It is apparent that the duration of therapy, the continuous supply of the patient with medication as well as the appropriate taking of medication are a prerequisite for efficacy of any drug and thus, for a successful therapy [ 11].
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Adherence to treatment regimens is a prerequisite for the efficacy and durability of any ART [ 5, 6].
Thus, the presence of functional, activated T cells, which are thought to be largely responsible for anti-tumour effects, is a prerequisite for the efficacy of the vaccine.
Intravenous bisphosphonates have been suggested to mitigate bone loss in patients at risk; however, correction of vitamin D deficiency might be a prerequisite for optimal efficacy in this vulnerable population.
Consequently, students should feel better prepared for practice which, in turn, is a prerequisite for self-efficacy – the extent to which a person believes that he or she can successfully fulfil a specific task in a specific context.
While Caucasian men present with 60 70% suppression to azoospermia, the prerequisite for full contraceptive efficacy, reports from China have shown contraceptive efficacy rates of >90% (15, 16).
Yet, optimal use of barrier precautions and a relatively high admission rate of intestinal carriage of resistant bacteria are prerequisites for the efficacy of intestinal decontamination.
This raises the question as to whether chronic receptor inhibition is a prerequisite for the clinical efficacy of 5-HT3 antagonints in general.
In fact, our observations illustrate in clinical practice that surgery-induced minimal residual disease is a prerequisite for a clinically relevant efficacy of DC vaccination (Smyth et al, 2001).
The limited binding capability of the bsAb to the anti-CD3 domain represents a particular characteristic of the optimized bispecific antibody construct, required for a repeated rolling of the retargeted T cells and thus, a prerequisite for the optimal killing efficacy with lowest unspecific side effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com