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This allowed allocation of the animals to BOB categories as a prerequisite for additional comparative analyses.
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Our results show that formation of dimers was not sufficient for the activation of TLR9 and an additional prerequisite for activation constituting a change in structural conformation might be necessary.
Therefore, the evolution of extensions at more common insertion sites might be a prerequisite for the evolution of additional helical structures within E23_14.
From this observation it may be concluded that proteasomal cleavage appears to be a prerequisite for nuclear translocation; although additional "activation" mechanisms may be operative.
Moreover, the RNA used was of excellent quality as assessed by Nanodrop and Bioanalyzer, a crucial prerequisite for reliable gene expression estimation (Additional file 8: Figure S5).
Overall, JAK2V617F presence is not a prerequisite for LT and more likely additional genetic events are required in the setting of disease transformation.
Thus, individualized products are in a lot of cases not just an additional feature but a prerequisite for successful curing.
A prerequisite for our meta-analysis was availability of additional array-data from the same tissue in estrogen-exposed fish.
On top, bisulfite treatment – a prerequisite for MGMT promoter methylation assays - introduces various additional DNA strand breaks resulting in highly fragmented single stranded DNA [30].
This additional qualification is not a prerequisite for caring for palliative patients.
Additional surgery was, however, a prerequisite for eradication of local disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com