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The preponderance values were used to rank categories allocated with a certain disease group.
Biological functions more strongly associated with one disease group compared to others were found by calculating preponderance values according to equation (7).
Calculation of preponderance values and GO term assignments were also performed with enrichment P-values reported by the DAVID Functional Annotation Tool [ 27, 28] as a public source of GO annotation.
For instance, preponderance values calculated for DAVID enrichment P-values ranked the GO categories "regulation of cell cycle" and "cell cycle" at position 86 and 88 (data not shown), respectively, whereas they were ranked 5th and 9th in the BKL analysis (Fig. 3).
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The preponderance value Prep is the smallest difference of P-values weighted by the relative proportion of the most significant P-value after logarithmic transformation.
Starting from enrichment P-values obtained with the standard test, we assigned GO biological processes to disease groups identified in this work and ranked them by a preponderance value that compares P-values of different gene sets (Methods).
All diseases were associated with at least one gene in corresponding gene sets, except for transient ischemic attack, so that results only apply to 62 of 63 disorders in cluster M. Fig. 3 shows the top 15 GO biological processes of each disease cluster ranked by preponderance value.
The great preponderance of these values will fall between 98.4 °F (36.9 °C) and 98.8 °F (37.1 °C).
This preponderance of narrative values follows a winter season in which City Ballet concentrated on full-length story ballets.
A third approach seeks the preponderance extreme R2 values across regions.
There seems to be among the biological processes correlating with lower SUV values a preponderance of biological processes related with the tumor microenvironment and its interaction with tumor cells (such as cell adhesion, cell motility, cytoskeleton reorganization, autophagy, and lymphangiogenesis).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com