The genome-wide analysis emphasizes the preponderance of pathway-dysregulation mechanisms over simple gene-malfunction as the main mechanism involved in the development of a cancer phenotype.
Similarly, alterations in cellular differentiation or tissue remodeling associated with muscle pathology could presumably account for the preponderance of these pathways.
In chronic inflammatory diseases, a preponderance of energy expenditure pathways is switched on, leading to typical hormonal changes such as insulin/IGF-1 resistance, hypoandrogenemia, hypovitaminosis D, mild hypercortisolemia, and increased activity of the sympathetic nervous system and the renin-angiotensin-aldosterone system.
Molecular studies have revealed the preponderance of the RAS RAF MAPK signaling pathway in the pathogenesis of OvLGSCa, thereby representing an attractive therapeutic target for patients affected by this disease.
Also, our results support the proposed preponderance of central carbon and anabolic pathways in the evolution of metabolism [ 2, 8, 27, 29].
The top 10 canonical pathways to which these 331 transcripts were mapped are presented in Table 3; these pathways exhibited a preponderance of various immune signaling functions.
The preponderance of neurotransmitter and nervous system signaling pathways among those significantly associated with our data echo reports that emphasize the role of the nervous system in the pathophysiology of peripheral inflammation and suggest a neurogenic inflammatory component for periodontitis (24).
P53 was most common and there was relative preponderance of mutations involving the PI3 kinase pathway: STK11, RICTOR, TSC2.
Every organ may be affected, with preponderance of lungs, kidneys, gastrointestinal tract and mucosal membranes.
These studies revealed a preponderance of differentially regulated genes involved in apoptotic pathways, suggesting that the extensive tissue damage characteristic of brain abscesses from MyD88 KO mice could result from dysregulated apoptosis.
Microarray analysis of infected MyD88 KO compared with WT mice revealed a preponderance of differentially regulated genes involved in apoptotic pathways, suggesting that the extensive tissue damage characteristic of brain abscesses from MyD88 KO mice could result from dysregulated apoptosis.
