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Amongst the multi-diet regulated genes in the testes, there was a preponderance of genes involved in energy regulation (Phgdh, Mrps15), post-translational modification (Nmt1), protein complex regulation and transport (Csda, Nalp6, Septin 10) and most importantly nucleic acid synthesis/regulation (Mcm3ap, Lars, Ncl, Nek7).
The preponderance of genes encoding for RGS proteins appears to be tissue specific.
A preponderance of genes whose known functions may be relevant in neuronal differentiation also factored into our selection of tags and clusters for validation.
This is supported by the preponderance of genes encoding cytochrome P450 enzymes among those that underwent a reduction in methylation from fetus to adult.
Ontological classification of deregulated genes using IPA uncovered a variety of functional categories similarly affected in both SCNT groups with a preponderance of genes required for biological processes.
This is somewhat surprising, as the preponderance of genes that have been lost from mitochondrial genomes in angiosperms have been functionally transferred to the nucleus.
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A similar family size is observed in amphibians (13 genes for Xenopus laevis, S.I.K., unpublished observation), whereas a preponderance of gene gains leads to an enlarged S100 repertoire size in mammals (23 acknowledged genes in humans [ 38]).
Many of these differentially expressed genes (DEGs) were detected at intermediate (between 5 and 9 d after dexamethasone treatment) and late (between 9 and 13 d) stages of flower development, and overall, a preponderance of gene activation over repression was observed (Table S1 in Additional file 1).
In contrast, gene deregulation by NUP98-HOXA9 and MLL-AF9 peaked at 3 days after introduction of the oncogene with a preponderance of upregulated genes: MLL-AF9 upregulated 244 genes and downregulated 151 genes; NUP98-HOXA9 upregulated 419 genes and downregulated 28 genes (Fig. 3 and Tables S7, S8, S9, S10, S11 and S12).
First, for misexpressed genes in hybrids the overwhelming preponderance of misexpressed genes follow a semi-dominant model of expression behavior because hybrid expression is intermediate and/or additive compared to expression differences between the two species (Table 2).
Notably, there was a preponderance of downregulated genes in both cases at 6 h: AML1-ETO upregulated 996 genes and downregulated 1771 genes; PML-RARA upregulated 271 genes and downregulated 675 genes (Tables S1, S2, S3, S4, S5 and S6).
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