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Compound 1 was prepared in a yield of up to 98% by the reaction of 1,4,10,13-tetraoxa-7,16-diazacyclo-octadecane (1,10-diaza-18-crown-6 ether) with 4-chloro-2-methyl-phenoxyacetic acid in a ratio of 1 2 (Figure 1). Figure 1 Synthesis of the title compound 1.
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Using E2 as the starting material and 1-iodo-6-benzyloxyhexane as a precursor for the C-7α side chain, a seven-step synthetic procedure afforded 3,17β-bis acetoxy -7α- 6-hydroxyhexanyl -estra-1,3,5(10)-triene (one of the derivatives prepared) in an overall yield of ∼45% as compared to other known procedures that afforded substantially lower overall yield (8–27%).
Bis phosphonomethoxy -acyclic nucleoside 311 was prepared in a 60% yield Bis phosphonomethoxy -acyclicof HDP tosylate 301 inucleoside
PGDLSR was successfully prepared with a yield of 31%.
[F]FPBZA can be prepared efficiently with a yield of 40 50%.
The 18F peptide tracer FPyPEGCBT-c RGDfK) (276–641 MBq) was prepared in yields oFPyPEGCBT-c RGDfK from end-of-bombardment over 1276 641MBq.
Radiotracer [18F]Pyricoxib was prepared in good radiochemical yields of about 27%% using 4-[18F]fluorobenzylamine as readily available 18F building block [25] within a substitution reaction using 2- methyl-sulfonyl -4- 4- methyl-sulfonyl phenyl -6- trifluoro-methyl -pyrimidine 2- methyl-sulfonyl -4- 4- methyl-sulfonyl phenyl -6- trifluoro-methyl -pyrimidine 2- methyl-sulfonyl -4- 4- methyl-sulfonyl phenyl -6- trifluoro-methyl -pyrimidine 2- methyl-sulfonyl -4- 4- methyl-sulfonyl phenyl -6- trifluoro-methyl -pyrimidine 2- methyl-sulfonyl -4- 4- methyl-sulfonyl phenyl -6- trifluoro-methyl -pyrimidine 2- methyl-sulfonyl -4- 4- methyl-sulfonyl phenyl -6- trifluoro-methyl -pyrimidine 2- methyl-sulfonyl -4- 4- methyl-sulfonyl phenyl -6- trifluoro-methyl -pyrimidine 2- methyl-sulfonyl -4- 4- methyl-sulfonyl phenyl -6- trifluoro-methyl -pyrimidine 2- methyl-sulfonyl -4- 4- methyl-sulfonyl phenyl -6- trifluoro-methyl -pyrimidine 2- methyl-sulfonyl -4- 4- methyl-sulfonyl phenyl -6- trifluoro-methyl -pyrimidine 2- methyl-sulfonyl -4- 4- methyl-sulfonyl phenyl -6- trifluoro-methyl -pyrimidine 1
Furthermore, calibration curves that are prepared in a reaction that is not affected by the inhibitor may yield biases.
The requisite 5-nitrooxindole, for condensation with 3 to form target compound 12, was prepared in 96% yield by a modified method of nitration of oxindole with HNO3/H2SO4 [33].
The 9-bromo substituted compounds 8a d were prepared in an 8-step synthesis in an overall yield of approximately 40%, and a library of 9-substituted analogues was prepared by cross-coupling reactions.
Complex 5 can also be prepared in 49%% yield from a one-pot reaction of 3 with TEMPO and two equivalents of DMAP.
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