The phase inversion temperature method was employed to prepare the formulations without the input of high pressure.
The results clearly suggest that the drug content of each formulation is within the theoretical range, indicating that the method used to prepare the formulations is suitable and reproducible in nature.
This may be due to the method (solvent evaporation) followed to prepare the SLN formulation.
The final solution was diluted with 9 mL of sterile water and 200 μL phosphate buffer concentrate to prepare the final formulation matrix containing 10%% ethanol.
In this work, various compositions of natural waxes, oils, and colorant were used to prepare the lipstick formulations.
The non-biodegradable positively charged polymer Eudragit RL 100 was used to prepare the different formulations with varying ratios of drug and polymer.
In fact, it was my responsibility to develop and prepare the preclinical formulations used for compound screening in animals.
The polymers Eudragit RS100 and Eudragit S100 were used to prepare the nanocapsule formulations NC-RS100 [25] and NC-S100 [26], respectively, and the polymer poly(ϵ-caprolactone) (PCL) was used to obtain the lipid-core nanocapsule formulation LNC-PCL [27].
To prepare the nanocapsule formulations (NC-RS100 and NC-S100), an organic phase (27 mL of acetone), containing the polymer (100.0 mg), CCT/product 1 (9:1, w/w) (333 μL), and sorbitan monooleate (76.6 mg) (except for NC-RS100), was injected using moderate stirring into a polysorbate 80 aqueous phase (76.6 mg in 53 mL).
PJ-S21 was freeze dried and used to prepare the following formulations: PEG suppositories (50%PJ-S21PJ-S21 PEG 1000, 5% PEG 1500); Fattibase suppositories (50%PJ-S21PJ-S21 Fattibase); and mucoadhesive instantly dispersible tablets (50%PJ-S21PJ-S21 HPMC, 20% Pharmaburst, 7.5% Carbopol 974P and 2.5% Carbophil).
High shear homogenization was used to prepare the SLN and formulation was optimized using Quality by Design The optimized Chol CUR SLN exhibited a narrow size distribution with a particle size of 166.4 ± 3.5 nm.
