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Most HSCT patients were able to provide real-time fatigue data even when experiencing multiple side effects from the preparatory regimen.
A new preparatory regimen for autologous bone marrow transplantation for patients with lymphoma.
CONCLUSION: The preparatory regimen consisting of lomustine/etoposide/cyclophosphamide is active in treating patients with lymphomas.
Thus, in adults receiving a nonmyeloablative preparatory regimen, the quantitative and qualitative recovery of T-cells occurs through rapid peripheral expansion.
Three patients died from this preparatory regimen, one of progressive interstitial pneumonitis, one of Legionella pneumonia, and one of multiorgan failure.
BACKGROUND: This trial studied the feasibility and efficacy of a new preparatory regimen for autologous bone marrow transplantation for patients with advanced lymphoid malignancies.
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This difficulty is in part because of the multiplicity of centers and protocols and the variability in patient eligibility and assessment, the extent of T-cell depletion, and the intensity of the preparatory regimens used.
These results compare favorably with data obtained with alternative preparatory regimens.
No significant differences were seen in survival data with the three preparatory regimens.
Three preparatory regimens, selected on the basis of prior therapy and pulmonary status, were employed.
T-cell recovery following myeloablative preparatory regimens and cord blood transplantation in adult patients gen erally occurs between 1 and 3 years following allogeneic bone marrow transplantation.
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