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The cutoff value at 60%% was used in the current clinical trial because the percentage of patients determined as chemosensitive had been 29.6, 28.6, and 47.3 % for 5-FU, CPT-11, and TXT, respectively, among 30 samples tested by the same investigators in a preparatory pilot study.
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However, pilot and preparatory activities are already occurring at a national level, largely funded by UN-REDD (a consortium of the FAO, UN and UNEP), the Forest Carbon Partnership Facility World Bankk), and individual governments, especially Norway [6].
To study how this can be done in practice, the commission proposes using a tool called Preparatory Action, essentially a pilot program funding collaborative defense research projects that paves the way for a fully-fledged military R&D component in future E.U. programs.
We speculate that this dilemma occurs as a result of insufficient preparatory work such as pilot studies to establish the likely change characteristic of the patient population of interest.
However, pilot and preparatory activities are already occurring at a national level, largely funded by UN-REDD (a consortium of the FAO, UN and UNEP), the Forest Carbon Partnership Facility World Bankk), and individual governments, especially Norway [ 6].
However, it should be noted that preparatory qualitative work and piloting receive far less attention in the DCE literature compared to experimental design and analysis, despite their importance in ensuring that choices are salient to the target population and therefore equal contribution to the robustness of results [ 29, 64].
The current pilot study was preparatory to the design of a larger prospective multicenter study assessing the prognostic value of brainstem dysfunction in sedated critically ill patients (ClinicalTrials.gov number: NCT02395861).
We conducted a pilot study (ISRCTN89462491) preparatory to a fully powered randomized, placebo-controlled trial to determine whether acupuncture reduces dyspnea in patients with lung or breast cancer.
This pilot study was preparatory work for a randomised controlled trial where the effectiveness of BLISS can be determined in a large sample in which accurate measures of nutrient and energy intake, and choking, are collected alongside biochemical iron status and growth data – the Baby-Led Introduction to SolidS study.
Thirdly, this preparatory phase was followed by a six-month pilot-testing period of the audit approach in each hospital (from January to June 2005).
This resulted in further modifications, and in the last preparatory step the questionnaires were tested in a pilot-study of 100 men with consequent revisions before the main study was initiated.
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