Sentence examples for preparative therapy from inspiring English sources
We designed a dose-escalation study to examine the maximum tolerated dose (MTD) of targeted I.V. busulfan with bolus etoposide as preparative therapy for autologous HSCT in AML.
busulfan (Bu, 9.6 mg/kg)/Cy (3.6 g/simustinetine (250 mg/m2) plus ATG (modified Bu/Cy plus ATG) as preparative therapy in T cell replete haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for acute leukemia.
No other preparative therapy was given.
Preparative therapy included either total body irradiation (1400 cGy) or busulfan (0.8 mg/kg every 6 hours, intravenously, adjusted for levels) in addition to cyclophosphamide or other chemotherapeutic agents.
These novel strategies include nonimmunologic therapies, such as targeted preparative regimens and posttransplant drug therapy, as well as immunologic interventions, including graft engineering, donor lymphocyte infusions, T cell engineering, vaccination, and dendritic cell-based approaches.
Simultaneous research efforts in several areas, including comorbidity assessment, novel preparative regimens, optimal pretransplant cytoreductive strategy, and post-transplantation therapies, are expected to improve long-term disease-free survival and quality of life.
The true cost of a therapy must also consider medical costs such as inclusion of lymphodepleting preparative regimens, length of hospitalisation and co-administration of other agents with the cells (Weber et al., 2011).
In this study, the novel TLI-based reduced intensity preparative regimen has allowed patients to avoid TBI and anti-T cell antibody therapy, yet rapidly achieved neutrophil engraftment with full donor chimerism in all patients.
Furthermore, TBI cohort had more CMV mismatches (44% vs. 38%, p=0.003) and had less cases with sensitivity to prior therapy (48% vs. 60%, p<0.001) as well as less cases with complete remission at the time or preparative regimen (33% vs. 25%, p<0.001).
Electrophoresis can also be used in a preparative mode.
