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JvG wrote the original study protocol, was involved in preparations of the study and provided intellectual input for the article.
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The proposed method was validated according to ICH guidelines, and successfully applied for the determination of pharmaceutical preparations of the studied drugs.
HD contributed to the study design, preparation of the study, analyzing of the data.
YI contributed to the preparation of the study, conducting of the measurements, and analyzing of the data.
HW, FG, CW, TH, AT, JS, and PC contributed to the preparation of the study, conducting of the measurements, and analyzing of the data.
Landuse/land cover map preparation of the study area for the years 1990, 2000 and 2009 has been done with the help of remote sensing technique.
HI and AH contributed to the study design, preparation of the study, conducting of the measurements, analyzing of the data, drafting of the manuscript, and critical revision of the manuscript.
YM, TN, and KT contributed to the study design, preparation of the study, conducting of the measurements, analyzing of the data, drafting of the manuscript, and critical revision of the manuscript.
We wish to thank Prof. Vittorio Girotto and Dr. Raffaele D'Isa for their help in the preparation of the study.
Kowa pharmaceutical participated in the preparation of the study design.
All authors contributed in preparation of the study.
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