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The aim of the study is to present the concept of novel method for fast screening of enteric coating compositions properties without the need of preparation of tablets batches for fluid bed coating.
Although the selected LSS for preparation of tablets exhibited the lower drug dissolution rate in pH 1.2, yet they showed bad flow properties.
For the preparation of tablets, the following excipients were used: lactose, microcrystalline cellulose, sodium crosscarmellose, colloidal silicon dioxide, magnesium stearate (Parafarm, Buenos Aires, Argentina), and Ludiflash (BASF, Ludwigshafen, Germany).
Kayitare et al. developed a tablet that can be accurately scored into eight segments [31], whereas Solomon and Kaplan patented a novel technology for the preparation of tablets containing drug-free layers to aid accurate division without compromising the accuracy of the delivered dose [32].
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The powder was used in the preparation of tablet using granulation and compression methods.
The preparation of tablet cut is described in our previous publication [ 10].
The above powder flow properties indicated that the solid SMEF can be used in preparation of tablet, pellets, and capsule dosage form.
The second component of the calibration strategy is the preparation of pressed tablets from ground concretion samples, including the reference material Nod-P1.
The compaction pressure of 12 kN was kept constant during the preparation of all tablets.
Storage test was performed on LSS selected for preparation of compressed tablets.
For the preparation of the tablets, an appropriate amount of polymer (about 200 mg) was magnetically stirred in water for 24 h.
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