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The Vatican has helped Anglican leaders with the preparation of key documents in the run-up to Lambeth.
The preparation of key alkyl-, andl- and heterobiaryl intermediates reported here highlights the potential of these cross-coupling reactions for medicinal chemistry and material science.
Preparation of key intermediate 131 began with ethyl 4-chloro-3-oxobutanoate 124.
FAO continues to provide strong support to UNFF, including through the secondment of a senior staff member to the Secretariat and the preparation of key documents for sessions.
UNICEF support to PBRM was mainly on capacity building on preparation of key PBMR tools namely the District Strategic Plan, (DSP), the Medium Term Expenditure Framework MTEFF) and use of Planning and Reporting (PlanRep) and giving feedback to the utility of these tools to the developers and implementers.
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1– 6 Enzymes are recognized as efficient catalysts for synthetic transformations, typically associated with high chemo-, regio-, and enantioselectivities, and have been used in preparations of key intermediates of high enantiomeric purities in, for example, the synthesis of pharmaceutically active species.
Starting from the X-ray structure of epothilone B, an original, non macrocyclic, structure has been designed to mimic the key structural features of this potent anticancer agent; the preparation of a key intermediate incorporating four stereogenic centers is described from cyclohexane-1,3-dione.
A new method for the preparation of the key intermediate compound 11 was proposed.
The synthetic sequence is centered around preparation of the key 3 5 -cyanomethyl-1,2,4-triazole intermediates and their Knoevenagel condensation with aromatic aldehydes.
The first example deals with the preparation of a key intermediate (2ag) for the synthesis of a patented melanin concentrating hormone receptor ligand (Fig. 2a 40 involved in the treatment of eating disorders, weight gain, obesity, depression and anxiety.
Hence, the preparation of their key chiral precursor (R -HPBE is of special and incR -HPBEly isterests.
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