Sentence examples for premature models from inspiring English sources

It may encourage scientists to swiftly come up with increasingly complex but conceptually premature models, involving poorly understood assumptions or mechanisms and too many additional adjustable parameters (for a discussion of a related problem in the context of individual actor models in the social sciences see Schnell 1990).

In summary, these observations suggest that p16 induction at weaning is sufficient to impose features of aging in multiple tissues by 6 weeks of age, among the most rapid premature aging models described (Hasty & Vijg, 2004; Kirkwood, 2005).

In order to better explore this observation, future studies will not only focus on obtaining larger numbers but also incorporate observations of macular development using premature mammal models and optical coherence tomography (OCT) evidence of retinal layer changes.

Upregulation of the apoptotic pathway has been identified in premature aging models including mice lacking the antioxidant enzyme copper/zinc‐dependent superoxide dismutase (CuZnSOD or Sod1) that exhibit accelerated sarcopenia (Jang et al., 2010), as well as interleukin‐10‐deficient mice that exhibit extreme frailty (Walston et al., 2008).

Brain and lung AUC values for the fitted premature infant model were about the same as those in the adult FDG model.

Thus, an inverse correlation could be drawn between Mof function, DNA repair and premature senescence (Model summarized in Figure 2).

Our findings suggest the possibility that GMF-TG mice might provide a novel premature-aging model useful in clarifying the relationship between aging, the pathophysiology of laminopathies and the clinical relevance for various chronic disease states.

Although once considered an acceleration of the normal physiological process, recent studies in antiprogestin- and infection-mediated premature cervical ripening models reveal distinct pathways of ripening as determined by differences in gene expression, immune cell populations, prostaglandin synthesis, hyaluronan expression, and collagen structure.

Mutations affecting nuclear genomic DNA repair lead to somatic stem cell (SSC) dysfunction and premature aging: mouse models with genomic DNA repair defects show progeroid phenotypes (Barlow et al., 1996; de Boer et al., 2002; Gu et al., 1997).

Finally, the results of our current study demonstrate that the glucose metabolite GO can induce cellular senescence in stem cells similar to the stress-induced premature senescence (SIPS) model [48].

This study was Institutional Animal Care and Use Committee (IACUC) approved and designed to determine whether this diet is better tolerated and equally effective to acidification with citric acid against gut colonization and subsequent bacterial translocation in a premature infant rabbit model.