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Ihh has been shown to induce the expression of PTHrP in resting-zone chondrocytes, which in turn inhibits the premature initiation of hypertrophy in proliferating cells4.
By inhibiting the activity of Cdc28/Clb cyclin-dependent protein kinase (CDK) complexes, Sic1 prevents the premature initiation of S phase in the yeast Saccharomyces cerevisiae.
But it's essentially the same as the one that crashed, with a few minor alterations, including a safety lock to prevent the premature initiation of the feathering system that led to the crash.
This caused a marked reduction in the smooth-bar fatigue strength in both microstructures, primarily because of the premature initiation of fatigue cracking resulting from the stress concentration associated with damage site and FOD-induced microcracking.
In addition, PROK1 may meditate the inflammatory cascade in myometrium during infection, resulting in premature initiation of labor.
There is considerable evidence that constitutive overexpression of cyclin E accelerates the G1 S phase transition, which can result in premature initiation of DNA synthesis.
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However, the underlying cellular and molecular mechanisms involved in the premature initiation and progression of IVD aging and degeneration still remains poorly deciphered (for review see [ 4]).
We hypothesized that these impacts could also cause premature initiation and headward expansion of channels because of lowered soil resistance and greater runoff accumulation as trails migrate upslope.
A higher load level and a lower current density allow for more sufficient oxidation of corrosion products with a larger volume expansion rate, leading to premature initiation and rapid propagation of corrosion cracking, and more obvious deflection development of RC beams.
High-cycle fatigue (HCF), involving the premature initiation and/or rapid propagation of small cracks to failure due to high-frequency cyclic loading, has been identified as one of the leading causes of turbine engine failures in aircraft.
The development of an in vitro translation system that recapitulates upstream 80S assembly on P. falciparum 5′ leaders will allow direct testing of premature initiation and its effect on translational efficiency in this parasite.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com