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The system captured worldwide attention after its premature implementation in February 2007, with problems in the design and before most of the infrastructure and system conditions required by its designers were in operation.
The basic problem was caused by the premature implementation before evaluation and clinical practice use in the 1990s.
Bergh criticizes the premature implementation of this technology based only on available data from phase I/II trials [ 51].
Indeed, commercialization activities and associated incentives have been linked to premature implementation of gene therapy research programs [ 49].
Moreover, diagnosing CD can be further challenged by premature implementation of dietary gluten avoidance before the definite diagnosis is made.
Premature implementation of stratified medicine approaches into clinical practice may be harmful if people who might otherwise benefit from treatment are denied access.
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Several respondents felt it was premature to expect implementation outcomes.
Decision frameworks and checklists are available to assess when provider incentives might do more good than harm, to help prevent premature or inappropriate implementation.
The need for a structured approach to judging readiness resonated strongly with SMEs, based on their experiences with premature and unsuccessful implementation.
Finally, Bootsma and Ferguson studied the 1918 influenza pandemic, and found that the timing of interventions can be critical, with delays in implementation and premature lifting of interventions reducing the impact of control measures [52].
For these counties, which include some of California's most heavily populated, the agency estimates the updated standards will lead to annual benefits of $4 9.1 billion in avoided health problems and premature deaths, with estimated implementation costs of $53 350 million.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com