According to our hypothesis premature aging disorders as well as normal aging should share features with mitochondrial disease.
Since this is the first study that examines the association with POS and smoking cessation, it seems premature to present hypotheses in this regard.
The following observations support this hypothesis: (i) premature transcription of the middle meiosis-specific genes disrupts this coordination causing premature entry into MI (Figure 6), and (ii) the pachytene checkpoint, which is activated upon defects in meiotic recombination and synapsis of homologs, inhibits NDT80 transcription, and consequently the middle genes [7], [35].
In contrast, several results supported the hypothesis that premature needlefall from infested trees provided a pulse of low C N needlefall that altered soil N cycling.
These findings strongly support our hypothesis that premature TCRαβ signals divert a proportion of TCRαβ+ DN thymocytes into the TCRγδ lineage.
Initially, this appears to give evidence against the hypothesis of premature aging in IDD.
There is a hypothesis that premature thelarche is a consequence of unintentional exposure to estrogen or estrogen-like substances (e.g., Li et al. 2002; Tiwary 1998).
Finally, we intended to evaluate the influence of age and disease duration on brain structural damage to further examine the hypothesis of premature ageing in myotonic dystrophies.
Within the lowest decile, insulin-treated patients had a greater mortality risk vs the reference decile (HR 1.79, 95% CI 1.45 2.22) than those not treated with insulin (HR 1.30, 95% CI 1.07 1.58), adding support to the hypothesis that premature death might relate to hypoglycaemia.
We may face difficulties in the rate of accrual, participant (patient and/or clinician) discomfort with being recorded, the Hawthorne effect, concerns related to multi-lingual data collection and analysis, social-desirability or premature disclosure of study hypotheses.
