Exact(6)
This is particularly relevant when frequent premature filter clotting is observed despite postfilter iCa results in the seemingly target range.
In septic shock patients undergoing CRRT, a low level of AT activity, with a threshold value of 70%, is associated with premature filter clotting.
Heparin treatment, especially in combination with extracorporeal circulation, may also lead to significant AT consumption [ 8], then to premature filter clotting despite adequate anticoagulation [ 9].
In the retrospective study by du Cheyron and colleagues [ 22] in sepsis patients requiring CRRT and with acquired antithrombin deficiency, anticoagulation with unfractionated heparin plus antithrombin supplementation prevented premature filter clotting.
In sepsis patients requiring CRRT and with acquired AT deficiency, anticoagulation with unfractionated heparin plus AT supplementation prevent premature filter clotting and may contribute to improving outcome, but the cost-effectiveness of AT remains to be determined.
Results of an analysis excluding all patients in whom sample collection could not be completed because of premature filter termination did not differ from those of an analysis of all patients (data not shown).
Similar(54)
Future trials should be powered to detect important clinical end points and be designed to avoid premature exhaustion of the filter.
In T.S.B. Q0572 issued on June 10, Land Rover says problems with the fuel filter may cause premature wear in the fuel pump.
Although premature coagulation of the CRRT filter is more common in children [ 21], 10% of our patients presented clinically significant hemorrhage, and there was a higher mortality among these patients.
To guarantee optimal sensitivity, filters to select variants that affect exonic sequence (Gene Location filter) or lead to a premature stop codon (VariantType filter) are applied in a transcript-specific manner.
Maintenance of the filter circuit is important, as premature disconnection results in loss of blood, increased nursing workload and increased costs [ 21].
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