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Some experiments and results reported here appeared in those preliminary publications; in this paper we also describe novel experiments with significantly larger datasets.
If these references can be treated as preliminary publications, I am inclined to advise that the an extract of the argument proving the algorithm be reiterated in the present manuscript.
While the preliminary publications of these results is unfortunate, and could be interpreted as stealing some of the authors' "thunder", the reviewers do not feel the authors should be penalized for this, as their manuscript puts all these observations into a more coherent interpretation than the previous studies, as well as showing high-resolution images.
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To facilitate this publication, results of two patients in the control group and 12 patients in the intervention group were unblinded by the statistician for purposes of the evaluation and preliminary publication.
The statistical analyses showed that a simple sum of the positive items from the diary with binary value (yes/no) has the same statistical performance as the disease-specific scoring system with graded values reported in the preliminary publication.
While several clinical observations suggest the potential induction of an abscopal effect with this approach, and a preliminary publication further generated enthusiasm 36, its ultimate additional benefit has not been clearly confirmed.
Although we find that your work is of interest, we regret to inform you that the findings at this stage are too preliminary for publication in eLife.
There was no safety information reported in the preliminary findings publication.[ 22] We did not find any studies on the use of BFRs in pain that met our inclusion criteria for efficacy.
However, they also stated that in its current form this work is somewhat too preliminary for publication, and thus additional experiments are needed to confirm the main conclusions and to further strengthen the manuscript.
Although the work is of interest, we regret to inform you that the consensus of the reviewers is that the findings at this stage are too preliminary for publication by eLife.
The WHO Working Group responsible for the fourth edition included some novel entities (see above); however, since the number of cases of some newly defined entities is limited, the assignment of grades remains preliminary, pending publication of additional data and long-term follow-up.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com