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Section "Preliminary experiments" presents the preliminary data collection and observation from the preliminary experiments.
We thank the Embryology staff and L. Morcom for their efforts on data entry, L. Wu and C. Mak for valuable discussion, M. Zamah for help with preliminary data collection.
YSY participated in preliminary data collection, data analysis, and writing the manuscript.
Cohort 1 was used for preliminary data collection to demonstrate that the selected doses of the two compounds would alter gene transcription.
For this preliminary data collection, eleven participants were recruited (4 females and 7 males, ages ranging from 19 to 23 years).
Preliminary data collection was performed through text matching by using the keyword as "olfactory receptor" along with the genome of our interest in the NCBI protein search.
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Unsupplemented neurotypical children, recruited as part of the preliminary baseline data collection [ 20] provided a reference range for nutritional and metabolic status for all of the measurements.
Given the above preliminary data, we anticipated data collection to span roughly 20 months.
Preliminary analysis during data collection, a stepwise analysis process with development of the coding tree, and reformulation of research questions as part of the analysis are recommended features of the method.
Saturation was determined through a preliminary analysis alongside data collection with discussion across the research team.
We must remind the reader that these results are highly preliminary and that data collection is incomplete.
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