The design, synthesis and preliminary activity of small molecular weight modulators of the heat shock protein 70 (Hsp70) are described.
Motivated by findings from preclinical studies showing potent synergistic activity with ricolinostat and lenalidomide, our goal was to assess the safety and preliminary activity of the combination of ricolinostat with lenalidomide and dexamethasone in relapsed or refractory multiple myeloma.
We aimed to determine the recommended phase 2 dose, safety, pharmacokinetics, and preliminary activity of tucatinib in combination with capecitabine or trastuzumab in patients with HER2-positive breast cancer with or without brain metastases.
The paper illustrates the preliminary activity of an extensive research program oriented to investigate the multiaxial fatigue behaviour of unidirectional composite laminates, with particular attention to the analysis of the damage mechanisms and their correlation with the local multiaxial stress state to be used then as the basis for the development of multiaxial fatigue criterion.
An additional objective was to explore preliminary activity of this combination.
Furthermore, a recent phase II study found preliminary activity of nab-paclitaxel monotherapy in patients who progressed on gemcitabine-based therapy.
These arms as well as adding to the global database of preliminary activity of this drug in these cohorts will also provide access for patients with these actionable molecular aberrations.
This first-in-human, phase I clinical trial of p28 (NSC745104), a 28-amino-acid fragment of the cupredoxin azurin, investigated the safety, tolerability, pharmacokinetics and preliminary activity of p28 in patients with p53+ metastatic solid tumours.
The secondary objectives were to (i) analyse the pharmacokinetic (PK) profiles, (ii) determine the safety profile (ii) determine the maximum tolerated dose (MTD) and (iv) evaluate preliminary activity of the combination of sorafenib and sirolimus.
This phase 1 study assessed the safety, tolerability, maximum tolerated dose (MTD), pharmacokinetics, pharmacodynamics and preliminary activity of intravenous (IV) ixazomib in relapsed/refractory lymphoma patients who had received ⩾2 prior therapies.
