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Exact(20)
For example, if nucleotide a is the preferred nucleotide at that site and it is preferred at an equal strength γfunc over all other nucleotides, whereas mutations between each two unpreferred nucleotides are selectively neutral, then: γ i, a) = γfunc = − γ a, i) for all i ≠ a and γ i, j) = 0 for all i, j ≠ a.
It was found that 'G' is the preferred nucleotide following the start codon AUG.
Hence, there are again four different substitution models, one for each preferred nucleotide.
Similar numbers of motifs (approximately 13 22%) showed cross-species differences in their preferred nucleotide sequences across other eutherians.
Four-fold degenerate codon usage is A/T biased in the third position, and T is the preferred nucleotide (Additional file 1).
On top of these is the subtle global tendency of a genome to move toward a preferred nucleotide composition and distribution that are characteristic for each clade.
Similar(40)
The efficiency of translation initiation is reduced if the sequence surrounding the AUG codon deviates significantly from certain preferred nucleotides.
The general Kozak consensus indicates a purine (A or G) at position − 3 and a G at position + 4 as preferred nucleotides [18].
Our goal was to search for nonidentical nucleotides (i and j) where species X prefers nucleotide i at the consensus site while species Y prefers nucleotide j at the same site.
Here we consider the simplest model of position-specific evolution with one preferred (consensus) nucleotide and three other (minor) nucleotides, the latter considered in a symmetric setting, without any selection or rate preferences [ 45].
We present a simple evolutionary model with a single preferred (consensus) nucleotide and the neutral substitution model adopted for all other nucleotides.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com