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As discussed previously, we also find support for the hypothesis that the mean optimal level of codon bias varies among genes and provide evidence that preferred mutations are effectively neutral in genes that may have a low optimal level of codon bias.
Hence selection will not act to increase any additional preferred mutations.
In fact, our results indicated RIP-like events with preferred mutations in CpG dinucleotides in both class I and II TEs.
Genes with the lowest estimates of Fop may have low equilibrium optimal levels of codon bias, and therefore additional preferred mutations are effectively neutral.
If natural selection favors translationally superior codons, the strength of selection should be positive for preferred mutations and negative for unpreferred variants.
On the other hand, we find a significant relationship between the strength of selection acting on preferred mutations and increasing levels of codon bias.
Similar(51)
In H3, amino acid substitutions were detected at three antigenic sites, A, B and E. The antigenic site position preferred for mutation was located at site A. Positions in the H1N1 isolates differentiating them from the A/Solomon Island/3/2006 like lineage and A/Brisbane/59/2007 like lineage were part of the antigenic Sa site.
If selection is preferred over mutation, the correlation (r) between the two quantities should be very high (r → −1).
An intriguing possibility is that, for a certain subset of patients at least, rpoB mutation is preferred over other VISA mutations because of a beneficial secondary phenotype.
It means that the genotypes are preferred in which mutations have little or no effect on fitness.
There seems to be a gain of strand polarity at G/C pairs in the V region in NBS patients, where the G residues on the top (non-transcribed, coding) strand were preferred targets for mutations (G/C ratio 1.9 vs. 1.4 in controls; χ2 test, p<0.05).
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