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Safety end points included vital signs, clinical laboratory parameters, 12-lead electrocardiogram, and adverse events (AEs; preferred terms coded according to the Medical Dictionary for Drug Regulatory Activities version 14.1).
Safety endpoints included changes in vital signs, weight, and clinical laboratory parameters, and adverse events (AEs; preferred terms coded according to the Medical Dictionary for Drug Regulatory Activities [MedDRA] version 16.1).
Tri-SSRs were preferred in coding regions, while di-SSRs were more common in non-coding regions.
But given that the majority of movement responses in our sample preferred gaze coding, it is fair to assume that the subcortical projection also predominantly contains a gaze code.
The comparative analysis of di-nucleotide compositions showed that UA, GU and UU preference in ncRNAs whereas CG, GA, GC, UC, AA and AC are preferred in coding RNAs (Additional file 1: Figure S1).
Neurophysiological studies in non-human primates show that individual neurons in primary motor cortex (M1) [2], [2], premotor cortex (PMC) [3], [4], and cerebellum [5] exhibit preferred direction coding (PDC) whereby the frequency of neural activity is highest in the preferred direction (PD) and progressively reduced as movements are made at increasing angular offsets from the PD.
If a search-based optimization is preferred, the code coverage criteria is suitable.
For example, NU2A3-A1NN contexts are mainly preferred in coding sequences (Figure 5) indicating strong differences between codon-pairs containing UpA dinucleotides and suggesting that translation does influence codon-pair choice.
