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Thus, short-range interactions involving the Met side-chain serve to preferentially select for tetramer formation, either by inhibiting a nucleation step essential for pentamer folding or by abrogating an intermediate required to form the pentamer.
A declining prevalence of K103N/S and Y181C/I overtime may be explained by the reduced usage of EFV and NVP which preferentially select for such mutations [ 24].
Using these criteria, we identified multiple methylation differences between KYSE180_HOTAIR and KYSE180 cells, suggesting that HOTAIR could preferentially select for DNA methylation in KYSE180 ESCC cells.
Routine submerged monolayer culture tends to suppress oral epithelial cell differentiation, has the propensity to select for proliferative subpopulations and may preferentially select for cells with repressed differentiation pathways.
DOI: http://dx.doi.org/10.7554/eLife.10319.004 To preferentially select for a specific binding mode (A or B), we prepared Doc sequences that incorporated 4 amino acid point mutations, referred to as quadruple mutants ('Q').
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Vincristine (all sublines) and doxorubicin (6/7 sublines) preferentially selected for pgp gene amplification and mRNA overexpression, whereas selection with etoposide resulted in a decrease of cleavable complex formation in 11 out of 13 sublines.
Of note, TCGA images from formalin-fixed paraffin embedded (FFPE) sections were preferentially selected for scoring due to better tissue histology; by contrast, the molecular analyses by TCGA were performed primarily on frozen unfixed tissue.
To counteract this bias, more challenging cases were preferentially selected for the test set, using striatal binding ratio results as a surrogate marker of the likely difficulty in classifying the data.
Thus, our data indicate that CCR5-using variants are not preferentially selected for within BM, suggesting that this tissue may not be responsible for the major bottleneck that occurs upon transmission [10].
Children with an IFN-γ ELISPOT response >100 SFC/106 PBMC were preferentially selected for inclusion in the study as these children were most likely to have a detectable change in gene expression as measured by qPCR.
Late erupting teeth (e.g. fourth premolars and third molars) were preferentially selected for sampling when available; however, due to limited sample availability some early erupting teeth and/or fragmentary specimens were sampled.
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