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We excluded one study because it preferentially enrolled smear-positive patients (Friedrich 2011) and two studies because they preferentially enrolled smear-negative patients (Ioannidis 2011; Moure 2011).
Many patients at our institution preferentially enrolled in the randomised trial following its launch in 2004.
We preferentially enrolled patients with thyroid cancers, due to the previously reported activity of sunitinib (Carr et al, 2010).
To overcome the relatively low statistical power in the screening stage, patients under 60 years old who developed cancer or who had a positive family history were preferentially enrolled in the screening stage, as mentioned in the methods section.
Differential enrollment could influence our results if patients with higher degrees of co-morbid conditions preferentially enrolled in the fee-for service system and did not participate in cancer screening or secondary diabetic prevention because of their other illnesses.
In BTC, a 13-15% tyrosine kinase domain mutation rate has been reported and it has been suggested that patients with tumor associated EGFR mutations be preferentially enrolled in clinical trials of EGFR-TKIs [ 17, 18].
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This dampens incentives to preferentially enroll low-risk patients with predictably lower health care expenses.
The NYC study (5 ) might have overestimated the proportion of infections that resulted in WNND because of a smaller sample size with wider CIs and selection bias resulting from symptomatic persons preferentially enrolling in the survey.
This selection could affect results if physicians were able to predict therapy response and if they preferentially screened and enrolled such patients for whom they expected a particularly favourable outcome.
This selection could bias results if physicians were able to predict therapy response and if they preferentially screened and enrolled such patients for whom they expected a particularly favourable outcome.
The most important fact was raised by the authors themselves [ 35, 39, 43], as they can not exclude the possibility that preferentially patients with a good prognosis were enrolled, since patients from both groups who died shortly after the diagnosis would not have entered the study.
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