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The probability for beneficial (adaptive) random changes, on the other hand, is not preferentially dependent on the ability to vary along the more restricted directions.
This may be explained by the findings of Redfield et al. [ 96], which revealed a DNA uptake specificity of the Hin subclade that is preferentially dependent on H. influenzae USS consensus sequence.
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In the submandibular gland (SMG) of mice, the granular convoluted tubule (GCT) develops preferentially in males dependent on androgens.
Finally, newborn neurons should be preferentially activated in hippocampal functions dependent on the dentate gyrus, such as pattern separation, as well as in discriminative learning tasks involving visual discrimination or spatial learning [28], [29].
A similar mating preference was also reported in C. elegans by Morsci et al. (2011), who found that C. elegans males preferentially mated with older hermaphrodites, dependent on the sperm status in the hermaphrodite.
We previously showed that full-length ataxin-3 binds both K48- and K63-linked Ub chains, yet preferentially cleaves K63 linkages in a manner dependent on the UIMs present in the C-terminus of ataxin-3 [14].
Both of these variation types, inter- and intra-loci variation, could be induced by specificity of DNMT3A and DNMT3B, which preferentially methylate specific CpGs at non-repeats, dependent on the underlying DNA sequence (34).
Large primary Si particles were found to act as preferential initiation sites by cracking or decohesion (dependent on test temperature) and are also sought out preferentially during short crack growth.
Can one be too dependent on trade?
The conversion of the prodrug capecitabine to 5-fluoruracil is dependent on thymidine phosphorylase, an enzyme preferentially expressed in malignant cells, and is considered tumour-selective (Ishikawa et al, 1998; Schilsky, 2000).
One prediction is that silvestrol should preferentially inhibit the translation of mRNAs whose expression is more dependent on eIF4F for ribosome recruitment.
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