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Preferential usage of the VH1-69 gene by V2 mAbs may depend on selection by the same antigenic structure.
In addition, we discovered a preferential usage of the heavy chain variable genes in the clonal IgG plasmablasts unique to each autoimmune condition and shared across these diseases.
Spectratyping analysis showed a preferential usage of Vβ12 and Vβ6 TCR gene families in 67% of HLA-DRβ1*0403-like genotyped monkeys.
The multiple binding sites could increase the affinity of LANA to the importin α/β complex providing preferential usage of the transport machinery.
As in the case of Comt, insertion of a B2 SINE in the 3' UTR of major histocompatibility complex genes results in preferential usage of a premature polyadenylation signal [15].
Autoreactive T cells with potential preferential usage of TCRs responsive to diabetes-related autoantigens may serve as both a potential marker for disease progression and a target for immune manipulation in autoimmune diabetes.
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The observed patterns for threonine are not only the preferential usage instead of 82 alanine and 41 asparagine but also replacements for 46 methionine and 31 serine.
Sperm competition is a widespread phenomenon that occurs in species utilizing a wide range of reproductive strategies, and a variety of different patterns of preferential usage, generally referred to as precedence, have been observed.
Once again, TCRβ chains remained relatively heterogeneous while TCRα sequences rapidly attain focused, preferential usage; although selected out of the same starting pool, the Th17 receptor usage is dissimilar to either Th1 or Th2 lines.
Although Vα and Vβ family expansion profiles differed between pigs in our study, particular types of TCR families showed preferential usage more frequently than other gene families in C-strain vaccine immunised pigs, suggesting common antigen specificity.
Seed enhancers have increased sequence conservation and show preferential usage in downstream somatic tissues, often expanding into super enhancers.
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