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Whatever the cause, our results show that HPV18 has a preferential risk for AdCx and ACIS.
Our previous, cross-sectional study indicated a preferential risk of HPV18 for the development of cancer from normal cytology (Bulk et al, 2006).
Nevertheless, whether the observed association between HPV18 and SCC is mainly caused by a preferential risk of HPV18 for the development if SCC, or by underdetection of HPV18 precursor lesions, our findings have important implications for evaluations of screening programmes.
In order to assess the preferential risk for cervical cancer and its precursors, type-specific prevalence of hrHPV types in cancer cases should be compared to type-specific prevalence in women without cancer.
This suggests that HPV16 and HPV18 are associated with a preferential risk compared to the other high-risk types of hrHPV for the development of either SCC or adenocarcinoma.
Possibly, even more efficient screening strategies can be developed by selecting hrHPV types conferring a preferential risk for the development of cervical cancer, and treat these infections more aggressively.
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More importantly, it reduces the risk of preferential flow and early thermal breakthrough, making microhole array-based EGS a more robust design.
Large P concentrations (0.23 1.02 mg P L−1) occurred in one plot that occasionally ponded, indicating P transport to depth by preferential flow is a risk in some soils on this landscape.
Results indicate that high temporal frequency soil moisture monitoring may be used to identify soil type – land use combinations in which the presence of preferential flow increases the risk of shallow groundwater contamination by rapid transport of agrochemicals through the soil profile.
This pinpointed rs11591377 (pmeta = 2.1 x 10-10 ) upstream of BMI1, residing within a hematopoietic stem cell enhancer of BMI1, and which showed significant preferential binding of the risk allele to MYBL2 (p = 1.73 x 10-5 ) and p300 (p = 1.55 x 10-3 ) transcription factors using binomial tests on ChIP-Seq data from a SNP heterozygote.
There is a risk that preferential targeting of carbon-dense peatland under REDD will worsen long-term prospects for biodiversity conservation in Indonesia by intensifying pressures to establish plantations in forested mineral soil areas that offer lower emission reduction potential (Table 1) but support richer biodiversity and higher concentrations of threatened species (Table 2).
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