The preferential downregulation by diet 2 of the methyltransferases with high Km for SAM may reflect a feedback inhibition on their own gene expression by unliganded or unused enzymes.
When dietary 2-AAF administration was for 3 or 7 days, removal of adducts was efficient and almost complete by 28 days on control diet, with preferential retention of dG-8-AF.
However, although HCDs can result in absolute VAT and SAT loss, these diets do not result in preferential abdominal fat loss.
It is known that cycling between high-calorie diets and low-calorie diets (weight cycling) 18 results in the preferential deposition of AT over non-AT mass 19 and this phenomenon often occurs in preterm infants when enteral feeds are discontinued because of concerns regarding feed intolerance and then restarted.
Indeed, combining a diet with sibutramine led to a preferential loss of VAT in patients with obstructive sleep apnea[ 45].
In this study a fish oil-enriched diet containing twice as much DHA as EPA showed a preferential incorporation of EPA.
A preferential incorporation of EPA was also observed in humans receiving a EPA-rich fish oil diet[ 32].
Hepatic DNA is hypomethylated in rats fed a folate depleted diet for 4 weeks (Balaghi and Wagner, 1993), while folate deficiency results in the preferential hypomethylation of exons 6 and 7 of p53 in rat colon (Kim et al, 1995).
Many phytoestrogens exhibit preferential activation of estrogen receptor beta (ERβ) over estrogen receptor alpha (ERα) [ 13], and diets high in phytoestrogen content have been correlated with lower incidence of hormone-related cancers, namely breast and prostate [ 14].
We aimed to elucidate preferential abdominal fat loss and the correlations between abdominal fat reductions and changes in CRFs achieved with a moderate low-carbohydrate diet (LCD) in patients with type 2 diabetes (T2DM).
