Exact(2)
Second, the allele frequencies of the SNPs does not vary between tumor types and subgroups, as might be expected if there was a preferential copy number change in a subset of tumors.
Third, it is much easier to achieve the required numbers of sequence reads to obtain all alleles: in the past, researchers have often relied on far fewer clones than the 20 to 40+ recommended [ 19, 22, 46] and so missing alleles may be an issue in many phylogenetic studies, especially if preferential copy amplification is common.
Similar(58)
One parameter describes the relative frequencies with which preferential attachment (copying) and innovation are used to make decisions, and the other describes the span of historical time used to observe the decisions which other agents have made.
For deletions, we can clearly reject the hypothesis that the small frequency of non-conservative events in our observed set is simply a result of the preferential deletion of copies within preexisting duplicates (p < 10-9, FishExactxacTestsTest
Preferential attachment: The new copy gets preferentially connected to genes with high connectivity [ 23, 24].
The inadequate expression of the selectable marker under the threshold of Hyg pressure (50 mg/l) may lead to preferential survival of high copy number cells with active HPT expression, as apparently occurred in experiments to transform tall fescue by the PEG mediated method under elevated selection pressure from increased Hyg concentration (200 mg/l) [ 42].
Preferential insertion of multiple copies of cognate TEs with different orientation into one "hot spot" may result in the formation of such locus.
This finding equally supports two hypotheses: long-term selection against insertion near genes versus the preferential insertion of new copies near genes pushing away old insertions.
comm)., and may be due to preferential amplification of nuclear copies of mitochondrial DNA [ 48] or the existence of RNA editing of this mitochondrial transcript, as has been observed in other nematodes [ 56].
To reduce the risk of preferential amplification of ITS copies, a phenomenon known as PCR-drift or PCR-bias [ 81], the products of two PCR reactions per individual were combined and used for ligations.
The possible roles of MITEs in the evolution of structure and function of plant genes were implicated by their preferential association with low-copy, genic regions [ 6, 7], and shown by several documented cases wherein the presence vs. absence of a particular MITE being correlated with expression states of the genes in question [ 4- 9].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com