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However, Tol2 displays preference to integrate near transcriptional start sites [35].
Overall, in both trials the MLV vector displayed a strong preference to integrate directly inside these regions as compared to the random reference (2% randomly simulated RIS n = 100,000; Fig 4A).
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The Tol2 element does not seem to have a consensus sequence for insertion at the primary DNA sequence level, but some studies show a pronounced preference for Tol2 to integrate close to transcriptional start sites (Grabundzija et al. 2010), CpG islands, and DNase I hypersensitive sites (Huang et al. 2010).
For instance, to inquire about patient preferences during a consultation, and to integrate these preferences into medical decision making.
The overall distribution of the vector integrants confirmed the classical preferences of MLV vector to integrate inside or in the proximity of coding regions (Table 2).
So far, goals, weights reference and utility functions have been used to integrate preferences in MOEAs [29].
Giving preference to "those who seem to integrate most readily" smacks of an imperialist attitude.
It makes no sense for America to limit the working opportunities of young Australians, or for EU countries to keep out Canadians.In the case of migrants from the poor world, countries should give preference to those who seem to integrate most readily.
We apply the arithmetic mean method as group decision rules to integrate expert preference.
Most transposons do not display strong target site preference but some are known to integrate site-specifically [ 42, 43].
For these less clear-cut decisions, like treatment of early-stage breast cancer, or whether to get prostate-cancer screening, S.D.M. aims to integrate patients' preferences and values into the weighing of each choice.
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