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Ranked from the most to the least favoured by participants, scenario 1 was the most preferred (preference position: median 1.00).
The next most desirable scenario was number 8 (preference position: median 3.00); 43.1% of patients preferred it in second place (n = 69).
Each zinc-finger domain was assigned a DNA binding preference (position weighted matrix) based on published methods (Kaplan et al., 2005).
The least favoured was scenario 3 (preference position: median 6.50), with 36.3% of participants placing it as the last option (n = 58).
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Different bioinformatic tools allow in silico predictions based on empirically derived rules for position-based residues preference (Position-Specific Scoring Matrix Methods, PSSM), Support Vector Machine (SVM) algorithms for machine learning (Linear or Radial Basis Function Kernel, Multiple Kernel Learning), or a Group-Based Prediction System (GPS) algorithm.
Cement is injected under careful fluoroscopic guidance and uni- or bipedicular injections can be applied depending on operator preference, positioning of the needles and success of cement injection.
Most 3′-end processing factors are conserved in eukaryotes; however, in some cases, the yeast and plant 3′-end processing factors differ from their mammalian counterparts in sequence preference, positioning and functionality, while a few do not have homologues in mammals.
Position preference parameter allows vehicles to drift towards their preferred position on road as observed in data.
The proposed model considers lateral position preference by each vehicle type and introduces a position preference parameter β in the model which facilitates gradual drifting towards preferred position on road, even if the gap in front is sufficient.
Inadequacy in lateral movement rules (Sect. 1 (1a)) is addressed by introducing a position preference parameter in the incentive criteria that reduces the probability of lane change as the distance between the target position and the preferred position increases.
The 6,248 spacers (from 2 × 3,124 successful input LE and RE oligonucleotides) that successfully recombined showed no base preference at position 8, but a trend towards guanine at each of the remaining five degenerate positions (Table 4).
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