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As Gene recalled, his talk, entitled "Sound Off," was "intended to be an informal one, and preferably experimental..
One possibility to overcome these problems is the inclusion of additional, preferably experimental information in the docking process.
Thus, the combination of p Ka and log P (calculated or, preferably, experimental) can serve to predict PLD induction for a given compound.
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Subsequent studies should preferably use experimental methods and include a larger group of patients to further investigate the perceived importance of the various quality indicators.
Definitive proof should be provided by blockade of the IL-7/IL-7R pathway, limiting intrinsic degenerative cartilage destruction in vitro and in vivo, preferably in experimental models of degenerative joint damage that mimic OA but with minor inflammation [ 3].
Preferably, such an experimental model would show reasonable pathogenesis congruency to human disease characteristics particularly in relation to placental sequestration/cytoadherence properties.
The datasets should derive preferably from different experimental conditions, e.g. different dose levels, pulses or ramp stimulations.
As we have used a supervised approach, a high quality training set (preferably based on experimental data, like the dbTSS) is essential, however.
One of the fundamental problems facing researchers carrying out gene expression studies is the use of control or reference genes that should not change, preferably under all experimental conditions.
Therefore, our results need confirmation from studies on the use of the two admission systems within one country, preferably using an experimental design to be able to control for other potential confounders like the type of coaching at school or the degree to which children have attended preschool classes, and with psychiatric assessments.
As the instrument could potentially be important for use in intervention studies, further testing of the QUOTE-Liver in its current form, preferably in an experimental setting where "bad" care is delivered purposefully, is needed in order to draw firmer conclusions on its sensitivity.
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