This suggests that even in studies with small sample sizes, multi-locus approaches are preferable to single-locus methods.
In GWAS, detecting epistasis (or gene gene interaction) is preferable over single locus study since many diseases are known to be complex traits.
Unlike Bayesian clustering (Pritchard et al. 2000; Guillot et al. 2005; Corander et al. 2008), these methods do not rely on explicit population genetics models, and they are preferable when many loci are available and the structure is subtle (Jombart et al. 2008, 2010; Reeves and Richards 2009).
As outlined in the Introduction, the comparison of multiple DSBR pathways at a single locus is preferable to the comparison of single pathways at multiple loci.
Firstly, targeting over-expression cassettes to the ku70 locus is preferable to random integration, which might lead to disruption of other coding sequences, or occur at transcriptionally silent/and or dispensable regions of the Z. tritici genome.
However, in many circumstances, including the targeting of genes required for viability or the precise insertion of exogenous DNA sequences, it will be preferable to directly target a locus for specific modifications.
Until an analytical solution to this question is developed, simulated data can provide insights into whether, given a fixed amount of sequencing effort, it is preferable to increase the number of loci or the sequence length of individual loci.
Therefore, for identification of reliable and informative SNPs, application of spherical filter is preferable over uniform since it effectively excludes loci with relatively high error rate compared to the information content.
Because significant time and investment is required to develop new multiplexes of 13+ STR loci, manufacturers indicated that it would be preferable to adopt a staged approach.
If HR events are desired, therefore, co-conversion approaches (Arribere et al. 2014; Ward 2015) where an oligonucleotide-templated HR event at one locus is used to enrich for a desired modification of a different locus, appear to be preferable to cloning transgenic F1 animals and analyzing their progeny.
