Preemptive testing, embedding this information into the EMR with appropriate decision support, and then seamlessly presenting it at the point of care when needed, rather than requiring tests to be ordered each time a relevant medication is prescribed, could help to minimize delay, cost, lack of follow-through, and duplicate testing.
Our study provides evidence in favor of preemptive PGx testing by identifying the risk of a variant being present in the population we studied.
Significant barriers, such as lack of professional guidelines, specialized training for interpretation of pharmacogenomics (PGx) data, and insufficient evidence to support clinical utility, prevent preemptive PGx testing from being widely clinically implemented.
PHASeR will utilize preemptive pharmacogenetic testing to help healthcare professionals make better, more informed decisions on medication.
A solution to this is preemptive genetic testing.
However, arguments around preemptive pharmacogenetic testing are often complex and based on models with missing information; we concur that further research is needed to inform the case.
However, preemptive genetic testing has life-long implications, and the physician must make the decision whether to disclose all of the patient's genetic information or just the information relevant to the current prescribing situation [ 74].
We reported recently convincing results in a phase II trial that tested a preemptive mAb therapeutic approach targeting PcRv in ICU P. aeruginosa colonized patients [ 8].
When using 'full preemptive isolation', an increasing test delay causes a slight increase in the number of averted infections.
The study tested whether preemptive "inoculation messages" can protect the beneficial effects of communicating the scientific consensus against real-world misinformation.
