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Expression of hypoxia-responsive genes is predominately regulated by hypoxia inducible factors (HIFs) [23], [25] [34].
This finding suggests that CDKN1C expression in breast cancer is predominately regulated by histone modifications instead of DNA hypermethylation.
One therefore might argue that apoptosis after acute PrPSc infection is predominately regulated by the intrinsic, mitochondrial apoptotic pathway.
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The regulation of changes in mRNA level is predominately regulated at the level of transcription while mRNA degradation is generally constant in mammalian cells [ 51].
The GluR6 results, shown in Figure 2, suggest that this receptor subtype is predominately regulated via MR in the DG, CA1 and CA3.
The GI tract is almost entirely surrounded by musculature (predominately smooth muscle) and regulated by the enteric neural plexus.
In mammals, Smc6 mRNA is predominately expressed in the testis and seems regulated by post-translational modifications.
In addition, the mouse profile suggests that o, p'-DDT elicited gene expression was predominately PXR regulated based on genes known to be regulated by PXR-, CAR- or PXR/CAR [ 20- 23].
ChIP-chip analysis was used to investigate promoter occupancy by liganded GR and revealed that GR was bound predominately near genes responsive to glucocorticoids in A549 lung cells and not at genes regulated by GR in other cell types examined [ 16].
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Regulated by mental health officials.
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