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The regulation of changes in mRNA level is predominately regulated at the level of transcription while mRNA degradation is generally constant in mammalian cells [ 51].
Furthermore, we investigated ET-1 only at the mRNA and not the protein level, since general consensus within the literature states that the bioavailability of the ET-1 protein is predominately regulated at the transcriptional level of the EDN1 gene [39].
However, changes in mRNA abundance of immune response genes play the dominant role in dynamic changes in protein levels, whereas the proteome of proteins performing basic cellular functions are predominately regulated at the level of protein translation or degradation [ 31].
Similar(57)
Expression of hypoxia-responsive genes is predominately regulated by hypoxia inducible factors (HIFs) [23], [25] [34].
This finding suggests that CDKN1C expression in breast cancer is predominately regulated by histone modifications instead of DNA hypermethylation.
The GluR6 results, shown in Figure 2, suggest that this receptor subtype is predominately regulated via MR in the DG, CA1 and CA3.
One therefore might argue that apoptosis after acute PrPSc infection is predominately regulated by the intrinsic, mitochondrial apoptotic pathway.
Using an AP-1-luciferase reporter system, we further revealed that FMOD significantly downregulated AP-1-mediated non-canonical TGFβ1 signal transduction (which predominately regulates TGFβ1 auto-induction and Pai1 expression) up to 24 h post-treatment (c).
Will they over regulate at that point?
In addition, the mouse profile suggests that o, p'-DDT elicited gene expression was predominately PXR regulated based on genes known to be regulated by PXR-, CAR- or PXR/CAR [ 20- 23].
Secondly, a recent study has shown that in Irf4−/−/Irf8−/− cycling pre-B cells, Akt activation is regulated predominately via IL-7 and not the pre-BCR.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com