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Cellular parkin distribution is shown in Figure 6E, with parkin predominately localized within the cytoplasm and at mitochondria forming autophagosomes.
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Notably, cofilin mutants that functionally mimic oxidation by a single mutation at oxidation-sensitive cysteins (Cys-39 or Cys-80) predominately localize within the mitochondria.
We show that LC3 predominately localizes with the mitochondria.
XBP-1s is a nucleus-localized protein and XBP-1u is predominately localized in the cytoplasm (Supplementary information, Figure S1A).
For example, gamma-secretase protein complexes that play a key role in neurodegenerative disease are predominately localized in plasma membrane and endo-lysosomal compartments [10].
However, MK were predominately localized to the spleen and blood with decreased numbers in the BM.
The mRNA for these proteins is predominately localized to neuronal cell bodies, but these soluble cytosolic proteins are likely to be transported down axons possibly distributing the protein across many structures of the brain.
The combined Q226L/G228S mutation exhibited a strikingly similar binding pattern to that shown by the H3 HA, with binding predominately localized to the apical surface of non-ciliated cells (Figure 4G versus 4B).
After 1 h, unmodified MSN were predominately localized at the site of injection (97.6%).
LMP2 immunoreactive cells were predominately localized in the penumbra surrounding the infarct core.
As shown in Figure 1f, both Flag-HECTD3 and caspsase-8 are predominately localized in the cytoplasm.
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