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Potocki Lupski syndrome, due to duplication of this same region, has recently been identified and described (Potocki et al. 2007) and it appears to be due predominantly to increased copy number of RAI1 (Molina et al. 2008).
Studies assessing the mechanisms of CMV-induced diaphragm muscle dysfunction have attributed the dysfunction predominantly to increased proteolysis [ 16- 18] with and without the requirement of oxidative stress [ 19, 20].
Studies have indicated an increase in vessel diameter in Notch-inhibited cell cultures [ 12], while others have shown in Dll4+/- retina microvasculature, vessel size is similar to wild type, and the increase in vessel density is attributed predominantly to increased sprout numbers [ 69].
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Liver exposure data indicate that the improvement in potency is predominantly due to increased metabolic stability of the siRNA conjugates.
Despite treatment advances, RA patients continue to have higher mortality and morbidity rates than the general population, predominantly related to increased atherosclerotic cardiovascular (CV) disease [ 1, 2].
Thus, OSA is associated with MS independent of obesity predominantly due to increased triglyceride, glucose and Epworth score values but not IR or microalbuminuria status.
Improving animal welfare is an increasingly important aspect of livestock production systems predominantly due to increased consumer concern about the source of animal products.
Similarly, dietary counseling, food fortification, and nutritional supplementation were found to have positive effects on weight gain in undernourished patients with COPD [ 241, 242] but improved weight gain was predominantly due to increased fat mass.
In this context, the reduced F-FDG uptake in dependent regions of the protective ventilation group, despite an increase in perfusion of these regions, suggests that the effect of the protective ventilation strategy on reducing F-FDG uptake was predominantly related to increased regional aeration.
As both RD (perpendicular to the axon) and AD (following the direction of the axon) contribute to FA (cartoon inset, Fig. 2), analysis of directionality demonstrated that the reduction in FA in the CC was predominantly due to increased RD but not AD (data not shown, P = 0.0436), supporting that FA reduction is more likely due to a myelin abnormality than an axonal pathology.
Down-regulation of PSII activity occurred predominantly due to increase in inactive reaction centers (RCs), decrease in electron transport per RC (ETO/RC) as well as per leaf cross-section (ETO/CSm) and enhanced energy dissipation.
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