Of note, however, even with an increased dose, the attainment of PD targets may still be unreliable, because beta-lactams have predominantly time-dependent kill characteristics, i.e., the time that the unbound (or free) concentration is above the MIC (f T>MIC) is the major PK/PD index associated with bacterial killing [51 53].
The activity of β-lactams is predominantly time-dependent and requires serum and tissue antibiotic concentrations above the minimal inhibitory concentration (MIC) of the pathogen to achieve adequate bacterial killing [ 6].
Status epilepticus models of epileptogenesis possess the advantage of a clear-cut progression from initial insult to chronic epilepsy in contrast to electrical kindling where a predominantly time-dependent protocol is usually administered.
Of note, however, even with an increased dose, the attainment of PD targets may still be unreliable, because beta-lactams have predominantly time-dependent kill characteristics, i.e., the time that the unbound (or free) concentration is above the MIC (fT>MIC) is the major PK/PD index associated with bacterial killing [ 51- 53].
Abnormal cycles exhibited by mice were predominantly prolonged time in estrus (with a few mice exhibiting prolonged time in diestrus).
It is shown that high temperature fatigue crack growth is predominantly loading time dependent with a weak effect of stress cycles.
My list is unintentionally predominantly day time stuff, proving there's a lot more to do on the island than just party!
Previous valuation studies had predominantly used time trade-off (TTO) to obtain social preferences from which value sets for EQ-5D health states could be modeled [ 2– 5].
Debrey et al. focused on comparing CE-MRA with time-of-flight MRA and studied sources of heterogeneity predominantly for time-of-flight MRA [ 24].
Moreover, the study recruited predominantly first-time mothers and since the barriers experienced by non-first-time mothers may be quite different, results may need to be confirmed in a broader sample of pregnant women for example including both first-time and non-first-time mothers.
The philosophy continued for the next four years, as the studio built on its commercial and critical reputation with four further features, all produced from rented offices by predominantly part-time staff.
