We found that, among protein enzymes involved in lipid metabolism, the lipogenic enzymes ACL and FAS were predominantly suppressed in both the WAT and liver in mice challenged by HFD feeding, in parallel with concomitant onset of hyperleptinemia.
Genes involved in cell adhesion, chromatin organization, cytoskeleton structure and regulation of transcription were predominantly suppressed following cisplatin exposure.
The iAUC analyses for IGF-1 and IGFBP-3 were performed by additionally subtracting baseline values because post-prandial values were predominantly suppressed below baseline.
Together, these findings suggest that voxels exhibiting predominantly suppressed and enhanced responses to repetition make distinct contributions to the computations underlying visual perception.
Single unit recording indicated that tonic TRN simulation predominantly suppressed thalamic firing rates, while at the same time promoting thalamic bursting.
The activation of Akt in the liver inhibits gluconeogenesis by predominantly suppressing the expression of genes for the key gluconeogenic enzymes, phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase).
Although ArcA predominantly suppresses the expression of genes required for oxidative metabolism, a small number of genes / operons are known to be activated by this transcription factor in response to hypoxia [ 6].
However, in both cell lines, the downregulation of FLIP mRNA expression was insufficient to account for the downregulation of FLIP protein expression, particularly at later timepoints, suggesting that vorinostat predominantly suppresses FLIP protein expression at a post-transcriptional level in these models.
By analyzing overlapping APA profiles from two APA biological replicates, we found that HLP1 mutation caused proximal-to-distal poly(A) site shifts in 2 274 transcripts compared with Col (P < 0.02, Fisher's exact test), suggesting that HLP1 is a 3′-end factor predominantly suppressing the usage of distal poly(A) sites.
Glucocorticoids elevate cellular cAMP levels by regulating the activity of both adenylyl cyclases and phosphodiesterases, predominantly by suppressing the activity of phosphodiesterases [ 19, 20].
