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In comparison, HNSCC is a highly heterogeneous disease with predominantly squamous cell carcinomas and only 30% of the study sample was expected to carry an HPV infection.
In the current study, all 12 cases were predominantly squamous cell carcinoma or mixed type.
Therefore, cancers are predominantly squamous cell carcinoma, adenocarcinoma, or basaloid and cloacogenic carcinoma.
Esophageal cancers in Shanxi are predominantly squamous cell carcinomas and adenocarcinomas are rare.
This led to the exclusion of patients with predominantly squamous cell histology from subsequent pivotal phase III studies of bevacizumab in NSCLC.
However, this study indicates that the exclusion of patients with predominantly squamous cell disease drastically reduces the risk of severe and fatal pulmonary hemorrhage.
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The majority of patients suffering from lung cancer are diagnosed with epithelial tumors (adenocarcinoma predominantly and squamous cell carcinoma represent ∼85% of all pathologically defined lung cancer cases).
(II) Adenosquamous carcinoma (case No. 0000016518): predominantly basaloid squamous cell carcinoma (T) with prominent DAB4-stained nucleoli (arrowheads); desmoplastic stromal reaction (S) with both DAB4-stained and unstained nuclei of stromal cells (arrow).
For example, the tumors from more than 95% of NPC patients in high-incidence areas of China are undifferentiated nonkeratinizing carcinoma, whereas those from patients of Western descent, such as Caucasian, African-American, and Hispanic patients, are predominantly keratinizing squamous cell carcinoma [ 3– 5].
This cytological misdiagnosis might be explained by suboptimal cellularity and the presence of predominantly anucleated squamous cells in the preparation.
However, the cellularity of this one false-negative smear was suboptimal and predominantly anucleated squamous cells were present.
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