SMF-1 may thus be the counterpart of NRAMP1 in the worm, being predominantly required for Fe uptake.
This observation is consistent with a previous study of Gram-positive Lactococcus spp. lipoprotein processing that found that lipid modification is predominantly required to retain proteins at the membrane cell-wall interface [36].
This task predominantly requires behavioural inhibition of premature responses that have negative consequences.
It was surprising to find that hsf-1 was predominantly required during development and again, to a lesser extent, during adulthood.
From our results it is plausible that during the pre-symbiotic stage, transcriptional activation by Nod-LCOs predominantly requires NSP1, but at the same time, yet unidentified regulators, e.g. GRAS TFs, might still come into play.
For both L1 and IAP the three mechanisms are in place within spermatogonia, however the derepression of IAP in MiliKO spermatogonia indicates that DNA methylation and or the piRNA pathway are predominantly required for the maintenance of IAP silencing therein.
Finally, it seems that Gsc and the Vent1/2 genes are predominantly required in their normal side of expression, while after removal of all three they seem to be dispensable for embryonic pattern formation.
One of such exercises might be soccer training as suggested by Paillard et al. (2006) who found that the level of expertise in soccer affected the COP spectral energy distribution in the M/L plane only and argued that soccer predominantly requires fine postural control in the M/L plane.
