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TNF-α is a key pro-inflammatory cytokine predominantly released by monocytes/macrophages in early sepsis.
Adipokines are cytokines that are predominantly released by adipose tissue into the bloodstream [ 28].
Although leptin is predominantly released by subcutaneous and not by abdominal fat tissue (5), its role in the development of obesity is certainly unquestioned.
This is perhaps surprising as ANP is released predominantly by atria and has much shorter half-life compared to BNP, which is predominantly released by the ventricle.
As expected, 5.8S rRNA sedimented in the lower gradient fractions owing its association with 25S rRNA, and was predominantly released by heat treatment (supplementary Fig S3 online).
Both MMP-1 and MMP-13 levels are enhanced in OA; MMP-1 is predominantly released by synovial cells, and MMP-13 is highly expressed by chondrocytes [ 46].
Similar(54)
SDS/PAGE resolved the intramolecular cross-links, which were present at approximately 50% of the total purified protein; in both cases the PPXD could be predominantly cross-linked or released, by exposure to either oxidizing or reducing agents.
Macrophage migration inhibitory factor is predominantly localised in the cytoplasm and released by a non-conventional secretion pathway (Merk et al, 2009).
This finding might indicate the mere pro-inflammatory potential of NGF as opposed to factors released by fibroblasts, which are predominantly involved in structural damage.
Destruction of cartilage matrix results predominantly from the action of connective tissue proteinase released by RA synovial tissues, chondrocytes, and pannus tissues.
The α1 antitrypsin enzyme is an anti-protease, acting predominantly to block the action of neutrophil elastase, a serine protease released by neutrophils.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com