Our understanding of these mechanisms is built predominantly on cell-culture studies of various cell types, although, additionally, animal models have been used to evaluate the requirement of specific proteins in IL-1β-mediated inflammation (Horai et al., 2000; Kuida et al., 1995).
It is expressed predominantly on cells of the hematopoietic lineage such as B lymphocytes, monocytes, granulocytes and activated T lymphocytes (for review see (Fang et al, 2010)).
CD40 is a member of the tumour necrosis factor (TNF) receptor superfamily and is expressed predominantly on haematopoietic cells, including B-cells, dendritic cells, monocytes, macrophages, activated B-cells and CD8+ T-cells (reviewed in van Kooten and Banchereau (2000)).
Characteristically, CD151 is present on cells juxtaposed with basement membranes and is localized predominantly on the cell surface in contact with this membrane [51].
A3-ARGFP and A3-ARYFP were expressed predominantly on the cell surface (Fig. 8 A ). Within the one field view, GFP and YFP fluorescence varied considerably from cell to cell, and as such, individual cells were grouped into GFP/YFP fluorescence ratios of 0.1 0.9, 1 9, and >10.
Upon co-injection with Frzb, the KDEL-tagged Wnt8 was not found on the cell surface (Fig. 6I) while Wnt8-HA was found predominantly on the cell surface (Fig. 6C).
CD34 expression on mature hematopoietic cells occurs predominantly on mast cells and eosinophils.
The ST2 transmembrane form is expressed predominantly on mast cells and Th2 cells.
Using immunofluorescence, both DOR and KOR proteins were expressed predominantly on the cell membrane with minor staining in the cytoplasm.
Existing studies of pattern formation by Rhos have focussed predominantly on explaining cell polarity.
